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Proteine und Peptide
Artikel-Nr:
(PRSI92-332)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-332
Lokale Artikelnummer::
PRSI92-332
Beschreibung:
ITIH3, which is short for Inter-alpha-trypsin inhibitor heavy chain H3, is a 890 aa. protein. It is secreted expression, and belongs to the ITIH family. I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin. ITTH3 may act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localisation, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI40-593)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
40-593
Lokale Artikelnummer::
PRSI40-593
Beschreibung:
GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant rat GM-CSF is a 14.5 kDa globular protein consisting of 128 amino acids residues. Recombinant human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites. Recombinant murine GM-CSF (40-617) is a 14.2 kDa globular protein consisting of 124 amino acids residues. Recombinant murine GM-CSF (40-621) is a 14.5 kDa globular protein consisting of 128 amino acids residues.
VE:
1 * 20 µG
Artikel-Nr:
(PRSI92-135)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-135
Lokale Artikelnummer::
PRSI92-135
Beschreibung:
Serpin B5 is a secretive protein that belongs to the Serpin (Serine Protease Inhibitor) family and Ov-serpin subfamily. Serpin B5 is expressed in the prostate, testis, intestine, tongue, lung, and thymus. Serpin B5 exhibits no serine protease inhibitory activity. Serpin B5 also functions as tumour suppressor an angiogenesis inhibitor. It has been shown that Serpin B5 blocks the growth, invasion, and metastatic properties of mammary tumours. Furthermore, high expression of Serpin B5 is linked to squamous cell carcinoma in non-small-cell lung cancer.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-392)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-392
Lokale Artikelnummer::
PRSI92-392
Beschreibung:
Adiponectin is a secreted protein. It is Synthesised exclusively by adipocytes and secreted into plasma. Adiponectin is an important adipokine that is involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Adiponectin Stimulates AMPK phosphorylation and activates in the liver and the skeletal muscle, enhancing glucose utilisation and fatty-acid combustion. Adiponectin also antagonises TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. It inhibits endothelial NF-kappa-B signalling through a cAMP-dependent pathway. Adiponectin may play a role in cell growth, angiogenesis and tissue remodelling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex: LMW, MMW or HMW.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-806)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-806
Lokale Artikelnummer::
PRSI91-806
Beschreibung:
R-spondin-3 (RSPO3), also known as Protein with TSP type-1 repeat, Roof plate-specific spondin-3, Thrombospondin type-1 domain-containing protein 2, PWTSR, THSD2 and CRISTIN1, is a member of the thrombospondin type 1 repeat supergene family. RSPO3 is a secreted protein and widely expressed in many tissues. RSPO3 contains two Furin-like repeats which have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases, and one TSP type-1 domain, RSPO3 founctions as a activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Otherwise, RSPO3 may negatively regulate the TGF-beta pathway.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-254)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-254
Lokale Artikelnummer::
PRSI90-254
Beschreibung:
DR6 is an orphan TNF receptor superfamily member belonging to a subgroup of receptors called death receptors. Expressed ubiquitously with high expression in lymphoid organs, heart, brain, and pancreas. Broadly expressed by developing neurons where it functions as pro-apoptotic factor. Recently, it has been reported that interaction with the beta-amyloid precursor protein (APP) activates a widespread caspase-dependent self-destruction program dependent on caspase-6.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-268)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-268
Lokale Artikelnummer::
PRSI91-268
Beschreibung:
Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an activator of Cyclin Type D-CDK4 complexes depending on its phosphorylation state and stoichometry.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-414)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-414
Lokale Artikelnummer::
PRSI90-414
Beschreibung:
CD152 (CTLA-4) and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD152 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD152 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD152 and CD28 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28.
VE:
1 * 500 µG
Artikel-Nr:
(PRSI91-885)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-885
Lokale Artikelnummer::
PRSI91-885
Beschreibung:
Interferon alpha/ beta Receptor 2 (IFN- alpha/ beta R2) is a single-pass type I membrane protein which belongs to the type II cytokine receptor family. It complexes with IFN- alpha/ beta R1 to form the signaling receptor complex for the family of alpha and beta IFN subtypes. By alternative splicing, IFN- alpha/ beta R2 can exist as a secreted soluble protein or as a type I membrane protein. IFN- alpha/ beta R2 is the principal ligand binding subunit of the receptor. Ligand binding is stabilized by the subsequent association with IFN- alpha/ beta R1, resulting in the formation of a signaling ternary receptor complex. IFNAR2 was detected in most lymphocytes, monocytes, and granulocytes, although IFNAR2 expression was higher in the monocytes and granulocytes than in the lymphocytes. Among the lymphocyte subsets, IFNAR2 showed high expression in natural killer (NK) cells and low expression in T lymphocytes. Isoform 1 and isoform 3 of IFNAR2 are directly involved in signal transduction due to their interaction with the TYR kinase, JAK1. Isoform 1 also interacts with the transcriptional factors, STAT1 and STAT2. Both forms are potent inhibitors of type I IFN activity.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI1021P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
1021P
Lokale Artikelnummer::
PRSI1021P
Beschreibung:
STAT1 alpha peptide is used for blocking the activity of STAT1 alpha antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-291)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-291
Lokale Artikelnummer::
PRSI90-291
Beschreibung:
Notch signalling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signalling is also involved in cellular processes through-out adulthood. Signalling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-527)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-527
Lokale Artikelnummer::
PRSI90-527
Beschreibung:
IL-24 is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. IL-24 appears to control cell survival and proliferation by inducing rapid activation of particular transcription factors called STAT1 and STAT3. It is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, psoriasis and cancer. IL-24 has antiproliferative properties is inhibiting angiogenesis and may contribute to terminal cell differentiation.
VE:
1 * 25 µG
Artikel-Nr:
(PRSI96-321)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-321
Lokale Artikelnummer::
PRSI96-321
Beschreibung:
FMS-like tyrosine kinase 3 ligand (Flt-3 Ligand) is also known as FL, Flt3L and FLT3LG, is an α-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages. FLT3LG is expressed as a noncovalentlylinked dimer by T cells and bone marrow and thymic fibroblasts. Each 36 kDa chain carries approximately 12 kDa of N- and O- linked carbohydrates. FLT3LG is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). FLT3LG acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It also induces the mobilisation of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3LG induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation. FLT3LG cooperates with IL2, IL6, IL7, and IL15 to induce NK cell development and with IL3, IL7 and IL11 to induce terminal B cell maturation. Animal studies also show FLT3LG to reduce the severity of experimentally induced allergic inflammation. FLT3LG is crucial for steady-state pDC and cDC development. A lack of FLT3L results in low levels of DCs.
VE:
1 * 20 µG
Artikel-Nr:
(PRSI92-394)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-394
Lokale Artikelnummer::
PRSI92-394
Beschreibung:
lysozyme C is a secreted protein and belongs to the glycosyl hydrolase 22 family. Lysozymes have primarily a bacteriolytic function, damage bacterial cell walls by catalyzing hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. Those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-328)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-328
Lokale Artikelnummer::
PRSI92-328
Beschreibung:
PRADC1, also known as C2orf7 or PAP21, is short for Protease-associated domain-containing protein 1. It is a 188 aa. with a 21 aa. signal, and the 171 located Asn can be glycosylated. PRADC1 has two mutagenesis which are N121Q and N171Q. This protein is secreted and highly expressed in skeletal muscle, heart and liver. It is expressed at intermediate level in kidney.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-225)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-225
Lokale Artikelnummer::
PRSI91-225
Beschreibung:
Oncomodulin-1 (OM) is a small, calcium-binding protein and a macrophage-derived growth factor, which can promote axon regeneration in retinal ganglion cells. Oncomodulin-1 is constitutively secreted by activated macrophages in the vitreous and retina in response to inflammatory conditions that promote optic nerve regeneration. Oncomodulin-1 binds RGCs with high affinity in vitro, but only when cAMP is pharmacologically elevated or if the membrane is permeabilized allowing Oncomodulin-1 access to the cytosolic compartment. Oncomodulin-1 is a member of the superfamily of calmodulin proteins and is a high-affinity calcium ion-binding protein and contains 2 EF-hand domains. OM is found in early embryonic cells in the placenta and also in tumors. It has some calmodulin-like activity with respect to enzyme activation and growth regulation.
VE:
1 * 50 µG
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noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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