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8 899 results were found
2-Fluor-p-toluonitril
Artikel-Nr:
(PRSI91-891)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-891
Lokale Artikelnummer::
PRSI91-891
Beschreibung:
Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains, lacks the intracellular signaling domain. As a result, binding of TRAIL to TRAIL R3 doesn’t transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-102)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-102
Lokale Artikelnummer::
PRSI92-102
Beschreibung:
Cytoplasmic Protein NCK1 (NCK1) is a cytoplasmic protein that contains one SH2 domain and three SH3 domains. NCK1 is a member of the adapter family, which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. NCK1 maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. NCK1 plays a role in the DNA damage response, but not in the detection of the damage by ATM/ATR. It is also involved in transducing signals from receptor tyrosine kinases to downstream signal recipients, such as ELK1-dependent transcriptional activation in response to activated Ras signaling.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-960)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-960
Lokale Artikelnummer::
PRSI91-960
Beschreibung:
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN- gamma by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI3845P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3845P
Lokale Artikelnummer::
PRSI3845P
Beschreibung:
RP105 peptide is used for blocking the activity of RP105 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-352)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-352
Lokale Artikelnummer::
PRSI91-352
Beschreibung:
Signal Regulatory Protein alpha (SIRP alpha) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRP alpha contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRP alpha can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRP alpha acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRP alpha shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRP alpha engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation
VE:
1 * 50 µG
Artikel-Nr:
(PRSI5769P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5769P
Lokale Artikelnummer::
PRSI5769P
Beschreibung:
SIRT4 peptide is used for blocking the activity of SIRT4 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI5415P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5415P
Lokale Artikelnummer::
PRSI5415P
Beschreibung:
IA-1 peptide is used for blocking the activity of IA-1 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI6755P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6755P
Lokale Artikelnummer::
PRSI6755P
Beschreibung:
TSHZ1 peptide is used for blocking the activity of TSHZ1 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI4019P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4019P
Lokale Artikelnummer::
PRSI4019P
Beschreibung:
BANF1 peptide is used for blocking the activity of BANF1 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-054)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-054
Lokale Artikelnummer::
PRSI90-054
Beschreibung:
The ST2 (Interleukin-1 receptor-like 1; Interleukin-33 receptor) gene was originally identified as a gene induced by serum or oncogene expression in fibroblasts. The gene produces a shorter soluble secreted form (ST2) and a longer, transmembrane form (ST2L) by alternative splicing. Soluble ST2 has been shown to downregulate the expression of TLR1 and TLR4. ST2L negatively regulates TLR4 signalling and induces endotoxin tolerance, and enhances Th2 responses. IL-33 is the specific ligand for ST2L.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI3881P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3881P
Lokale Artikelnummer::
PRSI3881P
Beschreibung:
TIP47 peptide is used for blocking the activity of TIP47 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI3517P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3517P
Lokale Artikelnummer::
PRSI3517P
Beschreibung:
PTEN peptide is used for blocking the activity of the PTEN antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI5143P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5143P
Lokale Artikelnummer::
PRSI5143P
Beschreibung:
APP peptide is used for blocking the activity of APP antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI96-482)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-482
Lokale Artikelnummer::
PRSI96-482
Beschreibung:
Protein jagged-1 (JAG1) is also known as Jagged1, hJ1, JAGL1 and CD339, which is a single-pass type I membrane protein containing one DSL domain and 15 EGF-like domains. JAG1 is widely expressed in adult and fetal tissues,the expression of JAG1 is up-regulated in cervical squamous cell carcinoma and also expressed in bone marrow cell line HS-27a.JAG1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. JAG1 is involved in early and late stages of mammalian cardiovascular development. JAG1 inhibits myoblast differentiation by similarity and enhances fibroblast growth factor-induced angiogenesis (in vitro).
VE:
1 * 50 µG
Artikel-Nr:
(PRSI40-592)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
40-592
Lokale Artikelnummer::
PRSI40-592
Beschreibung:
GDF-3 is a member of the TGF-β superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Unlike most TGF-β family members, GDF-3 and GDF-9 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia which characterizes Type 2 diabetes. Recombinant human GDF-3 is a 26.0 kDa non-disulfide-linked homodimer containing two 114 amino acid polypeptide chains.
VE:
1 * 20 µG
Artikel-Nr:
(PRSI90-374)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-374
Lokale Artikelnummer::
PRSI90-374
Beschreibung:
Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. It plays a dominant role in embryonic dorsalventral patterning, organogenesis, limb bud formation and bone formation and regeneration. BMP-2 signals through heterodimeric complexes composed of a type I receptor (Activin RI, BMP-RIA or BMP-RIB) and a type II receptor (BMP-RII or Activin RIIB). BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth and bone and cartilage repair. It induces ectopic bone formation or calcification by promoting osteogenic and chondrogenic differentiation in mesenchymal cells, stem cells and vascular smooth muscle cells. It also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells and is required for cardiac contractility.
VE:
1 * 50 µG
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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