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Proteine und Peptide
Artikel-Nr:
(PRSI92-285)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-285
Lokale Artikelnummer::
PRSI92-285
Beschreibung:
Lymphocyte cytosolic protein 2（LCP2）contains a SAM domain and a SH2 domain. It is highly expressed in spleen, thymus and peripheral blood leukocytes, T-cell and monocytic cell lines, but expressed at lower level in B-cell lines. LCP2 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. It is phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2 during post-translational modification. Studies using LCP2-deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-507)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-507
Lokale Artikelnummer::
PRSI90-507
Beschreibung:
Interleukin-18 (IL-18) is a costimulatory factor for production of interferon-gamma (IFN-gamma) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesised as a precursor 24kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE; Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. IFN-gamma is produced by activated T or NK cells and plays critical roles in the defense against microbiral pathogens. IFN-gamma activates macrophages and enhances NK activity and B cell maturation, proliferation and Ig secretion. IFN-gamma also induces expression of MHC class I and II antigens and inhibits osteoclast activation. IL-18 acts on T helper type-1 (Th1) T cells and in combination with IL-12 strongly induces them to produce IFN-gamma. Pleiotropic effects of IL-18 have also been reported, such as enhancement production of IFN-gamma and GM-CSF in peripheral blood mononuclear cells, production of Th1 cytokines, IL-2, GM-CSF, IFN-gamma in T cells and enhancement of Fas ligand expression by Th1 cells.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI5685P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5685P
Lokale Artikelnummer::
PRSI5685P
Beschreibung:
TMEM184C peptide is used for blocking the activity of TMEM184C antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI3201P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3201P
Lokale Artikelnummer::
PRSI3201P
Beschreibung:
ILPIP peptide is used for blocking the activity of the ILPIP antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI4109P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4109P
Lokale Artikelnummer::
PRSI4109P
Beschreibung:
NPAS3 peptide is used for blocking the activity of NPAS3 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI5295P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5295P
Lokale Artikelnummer::
PRSI5295P
Beschreibung:
IRGC peptide is used for blocking the activity of IRGC antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-059)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-059
Lokale Artikelnummer::
PRSI91-059
Beschreibung:
Human Interleukin family 1 Member 7 (IL1F7) is a member of the Interleukin 1 cytokine family. Five alternatively spliced transcript variants encoding distinct isoforms have been reported with distinct expression profiles. The longest IL1F7 transcript, referred to as IL1F7b or IL1F7 isoform 1, encodes a 218 amino acid residues proprotein containing a 45 amino acid propeptide, which is cleaved to generate mature protein. IL1F7b binds to IL18 R alpha with low affinity but does not exert any IL18 agonistic or antagonistic effects. IL1F7b also binds interleukin 18 binding protein (IL-18BP), an inhibitory binding protein of interleukin 18 (IL-18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL-18.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI40-620)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
40-620
Lokale Artikelnummer::
PRSI40-620
Beschreibung:
M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant rat M-CSF is a 18.1 kDa homodimeric protein containing two 155 amino acid polypeptide subunits.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI6211P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6211P
Lokale Artikelnummer::
PRSI6211P
Beschreibung:
BAPX1 peptide is used for blocking the activity of BAPX1 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-337)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-337
Lokale Artikelnummer::
PRSI92-337
Beschreibung:
Cytotoxic T-lymphocyte protein 4, is a single-pass type I membrane protein. It is widely expressed with highest levels in lymphoid tissues. CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI5501P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5501P
Lokale Artikelnummer::
PRSI5501P
Beschreibung:
ZNF536 peptide is used for blocking the activity of ZNF536 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI96-110)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-110
Lokale Artikelnummer::
PRSI96-110
Beschreibung:
Cluster of Differentiation 74 (CD74) is also known as HLA class II histocompatibility antigen gamma chain (HLADG), DHLAG, Ia-GAMMA, invariant chain (Abbreviated Ii). CD74 / HLADG is a polypeptide involved in the formation and transport of MHC class II protein. The cell surface form of the invariant chain is known as CD74. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation. CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI91-358)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-358
Lokale Artikelnummer::
PRSI91-358
Beschreibung:
Triggering Receptor Expressed on Myeloid Cells-Like Protein 1 (TREML1) is a single-pass type I membrane protein. TREML1 precursor contains a 15 amino acid signal peptide, a 147 amino acid extracellular domain with an Ig-like V-type (immunoglobulin-like) domain, and 128 amino acid cytoplasmic domain. It can be expressed exclusively in platelets and megakaryocytes (MKs). It is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML1 Sequestered in cytoplasmic vesicles in resting platelets. TREML1 be transported to the cell surface after stimulation by thrombin. Soluble fragments can be released into the serum by proteolysis. The phosphorylated TREML1 can interact with PTPN6 and PTPN11. TREML1 may participate in maintaining vascular hemostasis and regulating coagulation and inflammation at sites of injury.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-101)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-101
Lokale Artikelnummer::
PRSI91-101
Beschreibung:
alpha Crystallin B Chain (CRYAB) is a cytoplasmic protein that belongs to the small heat shock protein (HSP20) family. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. Alpha crystallins acts as molecular chaperones and hold them in in large soluble aggregates. CRYAB is expressed widely in many tissues and organs. It may contribute to the transparency and refractive index of the lens. The deficiency of CRYAB is the cause of myopathy myofibrillar type 2 (MFM2) and cataract posterior polar type 2 (CTPP2).
VE:
1 * 50 µG
Artikel-Nr:
(PRSI3473P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3473P
Lokale Artikelnummer::
PRSI3473P
Beschreibung:
Caspase-8 peptide is used for blocking the activity of Caspase-8 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-586)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-586
Lokale Artikelnummer::
PRSI92-586
Beschreibung:
Ephrins-A3 belongs the Ephrins ligand family which involved in a variety of biological processes, especially in the nervous system and in erythropoiesis. It is shown that Ephrin-A3 is expressed in brain, skeletal muscle, spleen, thymus, prostate, testis, ovary, small intestine, and peripheral blood leukocytes. Ephrin-A3 has a GPI anchor following the extracellular sequence and a signal sequence of 22 amino acids. Ephrin-A3 can bind EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8 and EphB1. Futhermore, it is associated with tumor growth and metastasis.
VE:
1 * 50 µG
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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