2-Fluoro-4-methyl-5-nitrophenyl+trifluoromethanesulphonate
Artikel-Nr:
(PRSIXP-5108BT)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
XP-5108BT
Lokale Artikelnummer::
PRSIXP-5108BT
Beschreibung:
Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that includes NGF, NT3, and NT4. All neurotrophins have six conserved cysteine residues and share a 55% sequence identity at the amino acid level. BDNF is a potent neurotrophic factor that supports the growth and survivability of nerve and/or glial cells. BDNF has been shown to enhance the survival and differentiation of several classes of neurons in vitro, including neural crest and placode derived sensory neurons, dopaminergic neurons in the substantia nigra, basal forebrain cholinergic neurons, hippocampal neurons, and retinal ganglial cells. BDNF is expressed within peripheral ganglia and is not restricted to neuronal target fields, raising the possibility that BDNF has paracrine or even autocrine actions on neurons as well as non neuronal cells. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients. In addition, functional studies showed that age-associated changes in BDNF-mediated pathways can enhance inflammation and increase myocardial injury after myocardial infarction in the aging heart.
VE:
1 * 50 µG
Artikel-Nr:
(BSENR-113-100)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
R-113-100
Lokale Artikelnummer::
BSENR-113-100
Beschreibung:
FUNCTION: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include SYT11, CCNE1, GPR37, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP and SEPT5. May play a more general role in the ubiquitin proteasomal pathway by participating in the removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of PARK2. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Regulates cyclin E during neuronal apoptosis. May represent a tumor suppressor gene. SUBCELLULAR LOCATION: Cytoplasm. Co-localizes with STY11 in neutrites. Co-localizes with SNCAIP in brainstem Lewy bodies. TISSUE SPECIFICITY: Highly expressed in the brain including the substantia nigra. Expressed in heart, testis and skeletal muscle. Expression is down-regulated or absent in tumor biopsies, and absent in the brain of PARK2 patients. Overexpression protects dopamine neurons from kainate-mediated apoptosis.
VE:
1 * 100 µl
Lieferant:
Thermo Fisher Scientific
Beschreibung:
Spritzen, Chromatographie, GC, Removable needle, gas tight, Volumen: 10000 µl, Spitzentyp: Bevel, Gauge: 22, Länge: 50 mm, VE: 1
Lieferant:
Texwipe
Beschreibung:
Dieses Zellulosepapier mit mittlerem Gewicht ist mit synthetischem Latex getränkt, wodurch die bei Standardpapieren übliche Freisetzung von Partikeln deutlich reduziert wird. Diese Papiere sind in DIN A4 und A3 erhältlich. Geeignet zum Schreiben und Drucken/Kopieren auf allen gängigen Bürogeräten.
Lieferant:
FLUOROCHEM
Beschreibung:
1,3-Bis(2-hydroxyhexafluorisopropyl)benzol
Lieferant:
Sigma-Aldrich
Beschreibung:
Natriumdichloracetat, Sigma-Aldrich®
Artikel-Nr:
(BOSSBS-15486R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15486R-HRP
Lokale Artikelnummer::
BOSSBS-15486R-HRP
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of Zinc-finger proteins contain a Kr_ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. HIC-2 (hypermethylated in cancer 2) possesses Zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought to be important for protein-protein binding, as well as for the binding of transcription factors. HIC-2 is also known as Hic-3, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing. HIC-2 is highly expressed in cerebellum and is localised to the nucleus in cells. HIC-2 contains a short amino acid sequence that is thought to interact with CtBP, a transcriptional repressor. The gene sequence associated with HIC-2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, suggesting that HIC-2 could possess tumor suppressor capabilities.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15486R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15486R-FITC
Lokale Artikelnummer::
BOSSBS-15486R-FITC
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of Zinc-finger proteins contain a Kr_ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. HIC-2 (hypermethylated in cancer 2) possesses Zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought to be important for protein-protein binding, as well as for the binding of transcription factors. HIC-2 is also known as Hic-3, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing. HIC-2 is highly expressed in cerebellum and is localised to the nucleus in cells. HIC-2 contains a short amino acid sequence that is thought to interact with CtBP, a transcriptional repressor. The gene sequence associated with HIC-2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, suggesting that HIC-2 could possess tumor suppressor capabilities.
VE:
1 * 100 µl
Artikel-Nr:
(FLUO001047-25G)
Lieferant:
FLUOROCHEM
Hersteller-Artikelnummer::
001047-25G
Lokale Artikelnummer::
FLUO001047-25G
Beschreibung:
N-Butylbenzylamin
VE:
1 * 25 g
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Artikel-Nr:
(COWI019.019.1)
Lieferant:
COWIE
Hersteller-Artikelnummer::
019.019.1
Lokale Artikelnummer::
COWI019.019.1
Beschreibung:
Thin wall joint sleeves, made of PFTE, are inserted between standard taper ground glass joints to eliminate the use of grease and prevent sticking.
VE:
1 * 1 ST
Artikel-Nr:
(MANA4007130022)
Lieferant:
MACHEREY-NAGEL
Hersteller-Artikelnummer::
4007130022
Lokale Artikelnummer::
MANA4007130022
Beschreibung:
Smooth filter papers particularly suited for technical applications such as industrial filtrations.
VE:
1 * 100 ST
Lieferant:
Sigma-Aldrich
Beschreibung:
N-Methyliminodiessigsäure, Sigma-Aldrich®
Lieferant:
FLUOROCHEM
Beschreibung:
4,4'-(Hexafluorisopropyliden)diphenol
Lieferant:
Sigma-Aldrich
Beschreibung:
Bromacetaldehyddiethylacetal, Sigma-Aldrich®
Artikel-Nr:
(817-0081)
Lieferant:
Thermo Fisher Scientific
Hersteller-Artikelnummer::
6319-0010
Lokale Artikelnummer::
NALG6319-0010
Beschreibung:
Diese druckempfindlichen Polyolefin-Etiketten von Nalgene™ können mit Fotokopierern, Laserdruckern und Tintenstrahldruckern verwendet werden. Sie lassen sich mit einer Vielzahl von Tinten beschreiben, einschließlich der Tinten von Kopierern, Markern, Kugelschreibern, Gelschreibern und technischen Markern (spezielle Tinten bitte vor Gebrauch auf ihre Eignung testen); nicht mit Bleistift beschreibbar.
VE:
1 * 800 ST
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