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Artikel-Nr: (PRSI91-765)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 91-765

Lokale Artikelnummer:: PRSI91-765

Beschreibung: Lymphocyte Antigen 6H (LY6H) is a novel member of the LY6 family of glycosylphosphatidylinositol-anchored cell surface glycoproteins. LY6H contains one UPAR/Ly6 domain. Human LY6H is synthesized as a 140 amino acid precursor that contains a 25 amino acid signal sequence, 20 amino acid propeptide that is removed in the mature form, and a 90 amino acid mature chain. LY6H is highly expressed in the brain (cerebral cortex, amygdala, hippocampus and subthalamic nucleus) and in acute human leukemic cell line MOLT-3. It is also found in lower levels in testis, pancreas, small intestine and colon. It has been shown that LY6H may play a role in both the central nervous system and the immune system.

VE: 1 * 50 µG

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Artikel-Nr: (PRSI96-519)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 96-519

Lokale Artikelnummer:: PRSI96-519

Beschreibung: Leukemia inhibitory factor, or LIF, an interleukin 6 class cytokine, is a protein in cells that affects cell growth and development.Leukemia Inhibitory Factor has several functions such as cholinergic neuron differentiation, control of stem cell pluripotency, bone & fat metabolism, mitogenesis of factor dependent cell lines & promotion of megakaryocyte production in vivo.
Removal of LIF pushes stem cells toward differentiation, but they retain their proliferative potential or pluripotency. Therefore LIF is used in mouse embryonic stem cell culture. It is necessary to maintain the stem cells in an undifferentiated state, however genetic manipulation of embryonic stem cells allows for LIF independent growth, notably overexpression of the gene Nanog. LIF is not required for culture of human embryonic stem cells.

VE: 1 * 20 µG

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Artikel-Nr: (PRSI33-919)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 33-919

Lokale Artikelnummer:: PRSI33-919

Beschreibung: CD45RA is an isoform of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C, respectively. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. CD45RA is expressed on 40-50% of peripheral CD4+ T-cells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin T-cells. T-cells expressing CD45RO are memory T-cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI34-194)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 34-194

Lokale Artikelnummer:: PRSI34-194

Beschreibung: A disulphide-linked heterodimer, consisting of mb-1 (or CD79a) and B29 (or CD79b) polypeptides, is non-covalently associated with membrane-bound immunoglobulins on B cells. This complex of mb-1 and B29 polypeptides and immunoglobulin constitute the B cell Ag receptor. CD79a first appears at pre B cell stage, early in maturation, and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. It is not present in myeloid or T cell lines. Anti-CD79a is generally used to complement anti-CD20 especially for mature B-cell lymphomas after treatment with Rituximab (anti-CD20). This antibody will stain many of the same lymphomas as anti-CD20, but also is more likely to stain B-lymphoblastic lymphoma/leukemia than is anti-CD20. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI38-244)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 38-244

Lokale Artikelnummer:: PRSI38-244

Beschreibung: Maspin was discovered as a mammary tumor suppressor that is expressed in normal mammary epithelium but lost in most breast cancer cell lines. While maspin is related to the serpin family of serine protease inhibitors, it may not function as a protease inhibitor. It plays an essential role in embryonic development through critical roles in cell adhesion. While the precise mechanism of maspin signaling is unclear, the tumor suppressing activity of maspin has been attributed to its ability to inhibit cell invasion/metastasis and angiogenesis, while promoting apoptosis. Nuclear translocation of active IKKbeta has been shown to repress maspin transcription and promote prostate cancer metastasis.

VE: 1 * 100 µG

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Artikel-Nr: (PRSIXW-8099)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: XW-8099

Lokale Artikelnummer:: PRSIXW-8099

Beschreibung: FUNCTION: Also acts as the receptor for echovirus 7 and related viruses (echoviruses 13, 21, 29 and 33).
SUBUNIT: Monomer (major form) and non-disulfide-linked, covalent homodimer (minor form).
PTM: The Ser/Thr-rich domain is heavily O-glycosylated.
SIMILARITY: Contains 4 Sushi (CCP/SCR) domains.
SUBCELLULAR LOCATION: Attached to the membrane by a GPI-anchor (isoform 2).
TISSUE SPECIFICITY: Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix.

VE: 1 * 50 µG

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Artikel-Nr: (PRSI5003)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 5003

Lokale Artikelnummer:: PRSI5003

Beschreibung: GAPDH Antibody: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD), an important energy-yielding step in carbohydrate metabolism. Recent evidence suggests that it also is involved in a number of cellular processes such as membrane fusion, phosphotransferase activity, DNA replication and repair, and nuclear RNA export. GAPDH has also been implicated in playing a role in different pathologies such as cancer progression, apoptosis, and neuronal diseases such as Alzheimer's and Huntington's disease. GAPDH is constitutively expressed at high levels in almost all tissues and cell lines making it ideal for use as a loading control marker in immunoblots.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI92-602)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 92-602

Lokale Artikelnummer:: PRSI92-602

Beschreibung: CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. CD40 is expressed in B cells, follicular dendritic cells, dendritic cells, activated monocytes, macrophages, endothelial cells, vascular smooth muscle cells, and several tumor cell lines. The extracellular domain of CD40 is characterised by Cysteine rich repeat regions. Interaction of CD40 with its ligand (CD40L) leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signalling pathways. Several different TRAF proteins (adaptor proteins) have been identified to serves as mediators of the signal transduction. CD40 plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.

VE: 1 * 50 µG

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Artikel-Nr: (PRSI33-995)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 33-995

Lokale Artikelnummer:: PRSI33-995

Beschreibung: Tumor Necrosis Factor Alpha (TNF alpha) is a cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line. [UniProt].

VE: 1 * 100 µG

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Artikel-Nr: (PRSI5445)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 5445

Lokale Artikelnummer:: PRSI5445

Beschreibung: Mimitin Antibody: Mimitin, a small mitochondrial protein, whose transcription is directly stimulated by c-Myc, is highly expressed in 80% of esophageal squamous cell carcinomas (ESCC). Suppression of Mimitin expression by RNA interference had no effect in cancerous cell lines such as human cervical carcinoma or hepatocarcinoma cell lines, but caused a decrease in cell proliferation in human glioblastoma, embryonic lung fibroblastic cells, and ESCC, suggesting Mimitin may play a special role in these types of cells. Mimitin expression is also regulated by MAPK kinases and IL-1, but not through the NF-kappa B-related pathway. It will interact with the microtubular protein MAP1S and can affect the activities of caspase-3 and -7 in cells stimulated to develop apoptosis. Other experiments suggest that Mimitin also acts as a molecular chaperone for the assembly of the mitochondrial complex I.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI3517)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 3517

Lokale Artikelnummer:: PRSI3517

Beschreibung: PTEN Antibody: PTEN (phosphatase and tensin homologue deleted on chromosome ten) is a dual-specificity phosphatase (with both protein and lipid phosphatase activity) first identified as a tumor suppressor gene. PTEN indirectly activates the AKT/PI3K pathway, an important signaling pathway for cell growth and proliferation by keeping levels of the second messenger PIP3 low, thereby preventing phosphoinositide-dependent kinase-1 (PDK-1) from phosphorylating and activating AKT. Expression of wild-type PTEN causes growth arrest in many cancer cell lines, but expression of a PTEN protein containing a mutation that blocks its lipid phosphatase activity failed to suppress growth of glioma cell lines suggesting that the tumor suppressive effect of PTEN is mediated solely by its lipid phosphatase activity. Other activities include the inhibition of insulin stimulated MAPK activation by blocking the insulin-receptor substrate (IRS)-1 phosphorylation and assembly of the IRS-1/Grb2/Sos complex.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI25-468)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 25-468

Lokale Artikelnummer:: PRSI25-468

Beschreibung: LDOC1 contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.

VE: 1 * 50 µG

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Artikel-Nr: (BOSSBS-10366R-CY7)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-10366R-CY7

Lokale Artikelnummer:: BOSSBS-10366R-CY7

Beschreibung: Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-2609R-CY7)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-2609R-CY7

Lokale Artikelnummer:: BOSSBS-2609R-CY7

Beschreibung: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.

VE: 1 * 100 µl

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Artikel-Nr: (PRSI33-090)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 33-090

Lokale Artikelnummer:: PRSI33-090

Beschreibung: This antibody recognises a glycoprotein of 44 to 88 kDa, which is identified as CD28. It is the critical Tcell co-stimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its co-stimulation role, CD28 functions in preventing Tcells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. it is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.

VE: 1 * 100 µG

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Artikel-Nr: (PRSI6437)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 6437

Lokale Artikelnummer:: PRSI6437

Beschreibung: LY6K Antibody: The lymphocyte antigen 6 complex locus K (LY6K), a member of cancer-testis antigen was initially identified as a molecular marker for head-and-neck squamous cell carcinoma as well a breast cancer. LY6K is a GPI-anchored membrane protein that is specifically associated with germ cell marker TEX101 and is strongly observed in testis, but only weakly in other tissues. LY6K mRNA was found to be upregulated in numerous bladder cancers due to gene amplification. Furthermore, knockdown experiments using LY6K siRNA reduced cell growth, migration and invasion in bladder carcinoma cell lines, suggesting that LY6K contributes to bladder cancer development.

VE: 1 * 100 µG

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