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BIOSENSIS PTY
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BIOSENSIS PTY
Artikel-Nr:
(BSENR-167-100)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
R-167-100
Lokale Artikelnummer::
BSENR-167-100
Beschreibung:
FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. SUBUNIT: Adaptor protein complex 1 (AP-1) is an heterotetramer composed of two large adaptins (gamma1/AP1G1 or gamma2/AP1G2 and beta1A/AP1B1 or beta1B/AP1B1), a medium adaptin (mu1A/AP1M1 or mu1B/AP1M2) and a small adaptin (sigma1A/AP1S1 or sigma1B/AP1S2 or sigma1C/AP1S3). SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle; cytoplasmic vesicle membrane; peripheral membrane protein; cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. TISSUE SPECIFICITY: Widely expressed. DISEASE: Deletion of the AP1B1 gene may play a role in the tumorigenesis of meningiomas. SIMILARITY: Belongs to the adaptor complexes large subunit family.
VE:
1 * 100 µl
Artikel-Nr:
(BSENTR-700-HQO)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
TR-700-HQO
Lokale Artikelnummer::
BSENTR-700-HQO
Beschreibung:
HQ-O Ready-To-Dilute (RTD) Stain Reagent is designed to label amyloid plaques in paraffin-embedded or freshly cut frozen tissue sections. As a fluorescent zinc chelator, HQ-O is unique as it takes advantage of the known presence of concentrated zinc in amyloid plaques. Studies with HQ-O revealed that fluorescent plaque-like structures are only seen when synthetic Aβx-42 is aggregated in the presence of zinc. Under blue light excitation, plaque structures appear bright green fluorescent in the brain parenchyma, correlating closely with plaque structures observed following Aβ antibody staining.
VE:
1 * 40 mL
Artikel-Nr:
(BSENR-1408-50)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
R-1408-50
Lokale Artikelnummer::
BSENR-1408-50
Beschreibung:
This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. The enzyme also binds to free monoubiquitin and may prevent its degradation in lysosomes (ref: SWISSPROT).
VE:
1 * 50 µl
Lieferant:
Biosensis
Beschreibung:
The oligomeric form of Amyloid Beta peptide (Aβ, 1- 42) has been closely linked to Alzheimer’s Disease. Several ELISAs targeting Aβ have been developed; however, these ELISAs are known to cross-react with Amyloid Beta precursor protein (APP) and are poorly characterised against monomeric and oligomeric forms of the peptide.
Artikel-Nr:
(BSENC-1527-100)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
C-1527-100
Lokale Artikelnummer::
BSENC-1527-100
Beschreibung:
Fatty acid-binding protein, adipocyte (ALBP) is a lipid transport protein which binds long chain fatty acids and other hydrophobic ligands and delivers them to their receptors in the nucleus. ALBP is found in the cytoplasm and nucleus of adipocytes.
VE:
1 * 100 µl
Artikel-Nr:
(BSENR-1820-50)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
R-1820-50
Lokale Artikelnummer::
BSENR-1820-50
Beschreibung:
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. Ref: uniprot.org
VE:
1 * 50 µl
Artikel-Nr:
(BSENC-1371-100)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
C-1371-100
Lokale Artikelnummer::
BSENC-1371-100
Beschreibung:
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. (Reference: uniprot.org)
VE:
1 * 100 µl
Artikel-Nr:
(BSENBEK-2231)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
BEK-2231
Lokale Artikelnummer::
BSENBEK-2231
Beschreibung:
The Biosensis Multi-Neurotrophin Rapid™ Screening ELISA Kit has been designed to allow rapid screening and quantification of NGF, BDNF, NT3 and NT4/5 in cell culture supernatants, lysates and brain extracts only if used as directed.
VE:
1 * 192 Tests
Artikel-Nr:
(BSENM-1372-250)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
M-1372-250
Lokale Artikelnummer::
BSENM-1372-250
Beschreibung:
Fibrillarin is part of the small subunit processome complex, involved in the processing of pre-18S ribosomal RNA. Nop1p is the yeast homologue of fibrillarin. Fibrillarin/Nop1p is extraordinarily conserved, so that the yeast and human proteins are 67% identical, and the human protein can functionally replace the yeast protein. This means that suitably cross-reactive antibodies to Nop1p/fibrillarin such as this antibody can be used to reveal nucleoli and study fibrillarin/Nop1p in all eukaryotes and archea tested to date. This antibody is becoming widely used as a convenient marker for nucleoli in a wide variety of species.
VE:
1 * 250 µl
Artikel-Nr:
(BSENR-097-100)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
R-097-100
Lokale Artikelnummer::
BSENR-097-100
Beschreibung:
FUNCTION: Seems to promote the survival of visceral and proprioceptive sensory neurons. SUBCELLULAR LOCATION: Secreted protein. TISSUE SPECIFICITY: Brain and peripheral tissues. SIMILARITY: Belongs to the NGF-beta family.
VE:
1 * 100 µl
Artikel-Nr:
(BSENR-1388-50)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
R-1388-50
Lokale Artikelnummer::
BSENR-1388-50
Beschreibung:
Neurofilaments contain three intermediate filament proteins: light (68 kDa), medium (160 kDa) and heavy (200 kDa). Neurofilament heavy (NF200 or NF-H) is phosphorylated and it is thought that this results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.
VE:
1 * 50 µl
Artikel-Nr:
(BSENGP-029-50)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
GP-029-50
Lokale Artikelnummer::
BSENGP-029-50
Beschreibung:
AGRP is the endogenous antagonist of alpha-melanocyte stimulating hormone and has been shown to cause potent stimulation of food intake, and this protein is found in over 90% of Neuropeptide Y containing cells in rats.
VE:
1 * 50 µl
Lieferant:
Biosensis
Beschreibung:
X63-saporin is an antibody conjugate comprising of the non-specific monoclonal IgG1 antibody X63, chemically conjugated via a reducible disulfide bridge to the ribosome-inactivating protein saporin, purified from saponaria officinalis. Antibody clone X63 has no known binding ability, and thus can be used as negative control antibody. In combination with saporin, X63-saporin is a useful negative control for targeting IgG1-saporin conjugates such as MC192-saporin.
Artikel-Nr:
(BSENC-1691-100)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
C-1691-100
Lokale Artikelnummer::
BSENC-1691-100
Beschreibung:
FUNCTION: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. SUBCELLULAR LOCATION: Cytoplasm; cytosol. Cell membrane. Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components. ALTERNATIVE PRODUCTS: 8 named isoforms produced by alternative splicing. Additional isoforms seem to exist. Isoforms differ from each other by the presence or absence of up to 5 of the 15 exons. One of these optional exons contains the additional tau/MAP repeat. TISSUE SPECIFICITY: Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system. DEVELOPMENTAL STAGE: Four-repeat (type II) tau is expressed in an adult-specific manner and is not found in fetal brain, whereas three-repeat (type I) tau is found in both adult and fetal brain. DOMAIN: The tau/MAP repeat binds to tubulin. In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments and straight filaments, mainly composed of hyperphosphorylated forms of Microtubule-associated protein Tau. Defects in Microtubule-associated protein Tau are a cause of frontotemporal dementia and parkinsonism linked to chromosome 17, as well as a number of other neurodegenerative diseases.
VE:
1 * 100 µl
Artikel-Nr:
(BSENM-1653-100)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
M-1653-100
Lokale Artikelnummer::
BSENM-1653-100
Beschreibung:
Anti-MCHERRY Mouse T4 Antibody [clone: 1C51]
VE:
1 * 100 µG
Artikel-Nr:
(BSENR-120-100)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
R-120-100
Lokale Artikelnummer::
BSENR-120-100
Beschreibung:
FUNCTION: This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by g proteins which activate adenylyl cyclase. PTHR2 may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTHR2 presence in neurons indicates that it may function as a neurotransmitter receptor. SUBUNIT: Binds to TIPF39/TIP39. SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. TISSUE SPECIFICITY: Abundantly expressed in brain, arterial and cardiac endothelium. Found as well in sperm, in the head of the epididymis. Lower expression is found in vascular smooth muscle, exocrine pancreas, testis and placenta. SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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