Sie suchten nach: Antikörper

Artikel-Nr: (BOSSBS-4056R-A488)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-4056R-A488

Lokale Artikelnummer:: BOSSBS-4056R-A488

Beschreibung: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

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Artikel-Nr: (BOSSBS-8375R-HRP)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-8375R-HRP

Lokale Artikelnummer:: BOSSBS-8375R-HRP

Beschreibung: The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the Ub C-terminus and the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ub-conjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. UBE2A (Ubiquitin-conjugating enzyme E2 A) and UBE2B (Ubiquitin-conjugating enzyme E2 B) are both Ub-conjugating enzymes that are essential to postreplication repair of UV-damaged DNA. UBE2A and UBE2B are both nuclear and cell membrane proteins that have been found to interact with Rad18.

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Artikel-Nr: (BOSSBS-8375R-A647)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-8375R-A647

Lokale Artikelnummer:: BOSSBS-8375R-A647

Beschreibung: The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the Ub C-terminus and the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ub-conjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. UBE2A (Ubiquitin-conjugating enzyme E2 A) and UBE2B (Ubiquitin-conjugating enzyme E2 B) are both Ub-conjugating enzymes that are essential to postreplication repair of UV-damaged DNA. UBE2A and UBE2B are both nuclear and cell membrane proteins that have been found to interact with Rad18.

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Artikel-Nr: (BOSSBS-8375R-A555)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-8375R-A555

Lokale Artikelnummer:: BOSSBS-8375R-A555

Beschreibung: The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the Ub C-terminus and the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ub-conjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. UBE2A (Ubiquitin-conjugating enzyme E2 A) and UBE2B (Ubiquitin-conjugating enzyme E2 B) are both Ub-conjugating enzymes that are essential to postreplication repair of UV-damaged DNA. UBE2A and UBE2B are both nuclear and cell membrane proteins that have been found to interact with Rad18.

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Artikel-Nr: (BOSSBS-4054R-A750)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-4054R-A750

Lokale Artikelnummer:: BOSSBS-4054R-A750

Beschreibung: S adenosylmethionine synthetase catalyses the formation of S adenosylmethionine from methionine and ATP. In mammalian tissues, there are three distinct forms of AdoMet synthases designated as alpha, beta, and gamma. Alpha and beta are expressed only in adult liver, while gamma is widely distributed in extrahepatic tissues.

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Artikel-Nr: (BOSSBS-9665R-A488)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9665R-A488

Lokale Artikelnummer:: BOSSBS-9665R-A488

Beschreibung: Plays a role in the incorporation of pigments into hair. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity).

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Artikel-Nr: (BOSSBS-9812R-A680)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9812R-A680

Lokale Artikelnummer:: BOSSBS-9812R-A680

Beschreibung: GCF, also known as C2orf3 (chromosome 2 open reading frame 3), transcription factor 9 (TCF-9) or DNABF, is a 781 amino acid nuclear protein that belongs to the GCF family. Widely expressed, GCF binds the GC-rich sequences of -Actin, EGFR and calcium-dependent protease (CANP) promoters. GCF contains multiple phosphoserine and phosphothreonine residues, and two GCF isoforms are produced due to alternative splicing events. GCF is considered a candidate for susceptibility to dyslexia (DYX3) as both genes reside in close proximity on human chromosome 2. Chromosome 2 is the second largest human chromosome and consists of 237 million bases, encodes over 1400 genes and makes up approximately 8% of the human genome.

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Artikel-Nr: (BOSSBS-9664R-FITC)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9664R-FITC

Lokale Artikelnummer:: BOSSBS-9664R-FITC

Beschreibung: DUX3 belongs to the paired homeobox family and contains 2 homeobox DNA-binding domains. It expressed in hepatoma Hep3B cells. DUX genes are present in 3.3-kilobase elements, a tandem repeat family scattered in the genome found on the short arms of all acrocentric chromosomes as well as on several other chromosomes. May be functional despite lack of introns and of a poly(A) addition signal. Two different isoforms are known.

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Artikel-Nr: (BOSSBS-9122R-CY7)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9122R-CY7

Lokale Artikelnummer:: BOSSBS-9122R-CY7

Beschreibung: F box protein 38 probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It may coactivate KLF7, but does not seem to promote KLF7 ubiquitination. There are three named isoforms.

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Artikel-Nr: (BOSSBS-12145R-CY3)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-12145R-CY3

Lokale Artikelnummer:: BOSSBS-12145R-CY3

Beschreibung: The CART gene encodes for a protein which has an important role in the regulation of appetite and body weight. The CART (cocaine- and amphetamine-regulated transcript) neuropeptide is an mRNA that changes in response to psychostimulant drug administration. Injection of CART peptides into the ventral tegmental area produces psychostimulant-like effects. CART localizes to areas of the central and peripheral nervous systems and is involved in feeding behavior when injected centrally. Expression of CART in the rat hypothalamus is modulated by nutritional status, and injection of synthetic CART peptide into the forebrain ventricular system suppresses food intake, indicating a possible role in hypothalamic control of energy homeostasis. Its identification in cell bodies and central terminals of vagal afferent neurons additionally suggests a role in brainstem mechanisms of meal termination and satiety.

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Artikel-Nr: (BOSSBS-9665R-CY5.5)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9665R-CY5.5

Lokale Artikelnummer:: BOSSBS-9665R-CY5.5

Beschreibung: Plays a role in the incorporation of pigments into hair. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity).

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Artikel-Nr: (BOSSBS-12145R-HRP)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-12145R-HRP

Lokale Artikelnummer:: BOSSBS-12145R-HRP

Beschreibung: The CART gene encodes for a protein which has an important role in the regulation of appetite and body weight. The CART (cocaine- and amphetamine-regulated transcript) neuropeptide is an mRNA that changes in response to psychostimulant drug administration. Injection of CART peptides into the ventral tegmental area produces psychostimulant-like effects. CART localizes to areas of the central and peripheral nervous systems and is involved in feeding behavior when injected centrally. Expression of CART in the rat hypothalamus is modulated by nutritional status, and injection of synthetic CART peptide into the forebrain ventricular system suppresses food intake, indicating a possible role in hypothalamic control of energy homeostasis. Its identification in cell bodies and central terminals of vagal afferent neurons additionally suggests a role in brainstem mechanisms of meal termination and satiety.

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Artikel-Nr: (BOSSBS-7891R-A555)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-7891R-A555

Lokale Artikelnummer:: BOSSBS-7891R-A555

Beschreibung: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II).

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Artikel-Nr: (BOSSBS-7891R-HRP)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-7891R-HRP

Lokale Artikelnummer:: BOSSBS-7891R-HRP

Beschreibung: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II).

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Artikel-Nr: (BOSSBS-1546R-A680)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-1546R-A680

Lokale Artikelnummer:: BOSSBS-1546R-A680

Beschreibung: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP2 beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.

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Artikel-Nr: (BOSSBS-7889R-A750)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-7889R-A750

Lokale Artikelnummer:: BOSSBS-7889R-A750

Beschreibung: CCNYL1 belongs to the cyclin family, Cyclin Y subfamily and contains 1 cyclin N terminal domain. The specific function of CCNYL1 is not yet known.

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