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Artikel-Nr: (PRSI90-432)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 90-432

Lokale Artikelnummer:: PRSI90-432

Beschreibung: Programmed death ligand 1 (PD-L1, B7-H1 or CD274) is a member of the growing B7 family of immune proteins that provide signals for both stimulating and inhibiting T cell activation. CD274 has been identified as one of two ligands for programmed death 1 (PD-1), a member of the CD28 family of immunoreceptors. CD274 is widely expressed in several organs such as heart, skeletal muscle, placenta and lung, and in lower amounts in thymus, spleen, kidney and liver. CD274 expression is upregulated in a small fraction of activated T and B cells and a much larger fraction of activated monocytes. CD274 expression is also induced in dendritic cells and keratinocytes after IFN-gamma stimulation. CD274 expression is also upregulated in a variety of tumour cell lines. Interaction of CD274 with PD-1 results in inhibition of TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. The CD274 - PD-1 pathway is involved in the negative regulation of some immune responses and may play an important role in the regulation of peripheral tolerance.

VE: 1 * 100 µG

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Artikel-Nr: (BOSSBS-7513R-A555)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-7513R-A555

Lokale Artikelnummer:: BOSSBS-7513R-A555

Beschreibung: BAI 1 protein is likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. It may function in cell adhesion and signal transduction in the brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-7985R)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-7985R

Lokale Artikelnummer:: BOSSBS-7985R

Beschreibung: This gene is thought to function in extracellular matrixremodeling and migration. It is predominantly expressed in theovary, but down regulated in ovarian cancer cell lines and primarycarcinomas, suggesting its role as a tumour suppressor. Mutationsin this gene have been associated with Hennekamlymphangiectasia-lymphedema syndrome, a generalized lymphaticdysplasia in humans. [provided by RefSeq, Mar 2010].

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9211R)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9211R

Lokale Artikelnummer:: BOSSBS-9211R

Beschreibung: SERPINB10 is a serine proteinase inhibitor of the ovalbumin like B clade of serpins. It was first discovered in human bone marrow in a search for serpins similar to SerpinB6. SERPINB10 was identified in lymphocytes, and was elevated in chronic myeloid leukemia and chronic myelomonocytic leukemia cells. The monocytic cell lines THP-1 and AML-193 also showed elevated SERPINB10 expression.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-7513R-A350)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-7513R-A350

Lokale Artikelnummer:: BOSSBS-7513R-A350

Beschreibung: BAI 1 protein is likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. It may function in cell adhesion and signal transduction in the brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-10153R-A350)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-10153R-A350

Lokale Artikelnummer:: BOSSBS-10153R-A350

Beschreibung: Detected at the highest levels in peripheral blood leukocytes and breast cancer cell lines. Found in leukocytes of the myeloid lineage, with the strongest expression observed in granulocytes and no detectable expression in lymphocytes. Expressed in thymic epithelial cells and fibroblasts.Belongs to the SECTM family.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-4221R-A750)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-4221R-A750

Lokale Artikelnummer:: BOSSBS-4221R-A750

Beschreibung: Involved in the conversion of lanosterol to cholesterol.Expressed in adult heart, brain, pancreas, lung, liver, skeletal muscle, kidney, ovary, prostate, and testis, but not detected in placenta, spleen, thymus, small intestine, colon (mucosal lining), or peripheral blood leukocytes.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-7513R)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-7513R

Lokale Artikelnummer:: BOSSBS-7513R

Beschreibung: BAI 1 protein is likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. It may function in cell adhesion and signal transduction in the brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-7513R-HRP)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-7513R-HRP

Lokale Artikelnummer:: BOSSBS-7513R-HRP

Beschreibung: BAI 1 protein is likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. It may function in cell adhesion and signal transduction in the brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-2684R-CY3)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-2684R-CY3

Lokale Artikelnummer:: BOSSBS-2684R-CY3

Beschreibung: The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-2684R-CY7)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-2684R-CY7

Lokale Artikelnummer:: BOSSBS-2684R-CY7

Beschreibung: The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-5957R-CY3)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-5957R-CY3

Lokale Artikelnummer:: BOSSBS-5957R-CY3

Beschreibung: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-10153R-A680)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-10153R-A680

Lokale Artikelnummer:: BOSSBS-10153R-A680

Beschreibung: Detected at the highest levels in peripheral blood leukocytes and breast cancer cell lines. Found in leukocytes of the myeloid lineage, with the strongest expression observed in granulocytes and no detectable expression in lymphocytes. Expressed in thymic epithelial cells and fibroblasts. Belongs to the SECTM family.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-7745R-A350)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-7745R-A350

Lokale Artikelnummer:: BOSSBS-7745R-A350

Beschreibung: Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner.Tissue specificity: Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-7745R-A488)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-7745R-A488

Lokale Artikelnummer:: BOSSBS-7745R-A488

Beschreibung: Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner.Tissue specificity: Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-0823R-FITC)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-0823R-FITC

Lokale Artikelnummer:: BOSSBS-0823R-FITC

Beschreibung: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.

VE: 1 * 100 µl

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