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BIOSS INC
Artikel-Nr:
(BOSSBS-3181R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3181R-A750
Lokale Artikelnummer::
BOSSBS-3181R-A750
Beschreibung:
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13123R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13123R-A680
Lokale Artikelnummer::
BOSSBS-13123R-A680
Beschreibung:
EXTL3 is a member of the EXT (hereditary multiple exostosin) gene family of tumor suppressors encoding glycosyltransferases involved in heparan sulfate (HS) biosynthesis. Within this family, the C-terminus is conserved between all members from C. elegans to vertebrates. EXTL3 is a ubiquitously expressed, developmentally regulated, single-pass type II membrane protein that localizes to the endoplasmic reticulum membrane. EXTL3 adds N-acetylglucosamine (GlcNAc) to the polysaccharide-protein linkage region and to the growing HS chain suggesting that it plays a role in both the initiation and elongation of HS chains. In addition, EXTL3 may act as a Reg receptor, binding Reg via its N-terminus.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0274R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0274R-A680
Lokale Artikelnummer::
BOSSBS-0274R-A680
Beschreibung:
C Peptide is part of the molecule of Proinsulin, that consists of three parts: C Peptide and two long strands of amino acids (called the alpha and beta chains) that later become linked together to form the insulin molecule. From every molecule of proinsulin, one molecule of insulin plus one molecule of C Peptide are produced. C peptide is released into the blood stream in equal amounts to insulin. A test of C peptide levels will show how much insulin the body is making. Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5284R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5284R-A680
Lokale Artikelnummer::
BOSSBS-5284R-A680
Beschreibung:
Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11457R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11457R-A750
Lokale Artikelnummer::
BOSSBS-11457R-A750
Beschreibung:
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9747R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9747R-A680
Lokale Artikelnummer::
BOSSBS-9747R-A680
Beschreibung:
Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKRD20A (ankyrin repeat domain-containing protein 20A) is an 823 amino acid protein that contains five ANK repeats. The gene encoding ANKRD20A maps to chromosome 9, which consists of about 145 million bases and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterised by harmful vascular defects, and familial dysautonomia are associated with chromosome 9. Also, chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukaemias.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8566R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8566R-CY5
Lokale Artikelnummer::
BOSSBS-8566R-CY5
Beschreibung:
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10020R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10020R-A488
Lokale Artikelnummer::
BOSSBS-10020R-A488
Beschreibung:
Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8121R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8121R
Lokale Artikelnummer::
BOSSBS-8121R
Beschreibung:
Anti-CCDC153 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11217R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11217R-A350
Lokale Artikelnummer::
BOSSBS-11217R-A350
Beschreibung:
Myotubularin-related protein 14 (MTMR14), also known as Jumpy, is a myotubularin-related phosphoinositol-3-phosphate (PI3P) phosphatase (1). Mutations in the MTMR14 gene have been associated with centronuclear myopathy (1). MTMR14 deficiency in mice leads to altered calcium homeostasis and muscle disorders (2). MTMR14 has also been shown to play a role in autophagy, a process that is highly regulated by phosphatidylinositides through the type III PI3K, Vps34 (3). MTMR14 was localized to autophagic isolation membranes and early autophagosomes (3). In these studies, MTMR14 inhibited autophagy and mutations of MTMR14 associated with centronuclear myopathy were also defective in autophagy inhibition. In zebrafish, MTMR14 knockdown was shown to increase the number of autophagosomes, suggesting that its activity is associated with an inhibition of autophagy (4).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5712R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5712R-A647
Lokale Artikelnummer::
BOSSBS-5712R-A647
Beschreibung:
FGFR1 Oncogene Partner is required for anchoring microtubules to the centrosomes. Ubiquitous; highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas. A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). There are three named isoforms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5630R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5630R-A350
Lokale Artikelnummer::
BOSSBS-5630R-A350
Beschreibung:
Synapsin I is a member of the synapsin family. Synapsins are neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations of the Synapsin I gene may be associated with X linked disorders with primary neuronal degeneration such as Rett syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2668R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2668R-FITC
Lokale Artikelnummer::
BOSSBS-2668R-FITC
Beschreibung:
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6035R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6035R-CY7
Lokale Artikelnummer::
BOSSBS-6035R-CY7
Beschreibung:
Carboxypeptidase A2 (CPA2) is one of three different isoforms of human pancreatic carboxypeptidase A. Carboxypeptidase A2 acts on aromatic C-terminal residues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10113R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10113R-CY7
Lokale Artikelnummer::
BOSSBS-10113R-CY7
Beschreibung:
Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8500R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8500R-FITC
Lokale Artikelnummer::
BOSSBS-8500R-FITC
Beschreibung:
Membrane microdomains known as lipid rafts are implicated in B-cell activation during B-cell receptor (BCR) signal initiation. Raftlin-2, also designated RFTN2 (raftlin family member 2) or raft-linking protein 2, is a 501 amino acid cell membrane protein that is essential for raft cell assembly and maintenance. A lipid anchor protein, Raftlin-2 belongs to the raftlin family and is encoded by a gene that maps to human chromosome 2q33.1 and mouse chromosome 1 C1.2. Human chromosome 2 is the second largest human chromosome, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstré°‰ syndrome is due to mutations in the ALMS1 gene.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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