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BIOSS INC
Artikel-Nr:
(BOSSBS-7068R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7068R-A488
Lokale Artikelnummer::
BOSSBS-7068R-A488
Beschreibung:
FOXO1 + FOX3 + FOX4 belong to the forkhead family of transcription factors. FOXO1 (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined. FOX3 probably functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of the FOXO3 gene with the MLL gene is associated with secondary acute leukemia. FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6539R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6539R-A488
Lokale Artikelnummer::
BOSSBS-6539R-A488
Beschreibung:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5846R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5846R-A647
Lokale Artikelnummer::
BOSSBS-5846R-A647
Beschreibung:
ADAM11 was first described as MDC (Metalloproteinase-like disintergin-like cysteine-rich protein) from analysis of human brain libraries, in search of brain-specific proteins. Two splice variants with different carboxyterminal ends were described. The message was found only in the brain in this publication. Another group identified ADAM11 in the human brain, where ADAM11 was thought to be involved in cell migration and spatial patterning. ADAM11 was mapped to 17q21.3, a region of interest for breast cancer, and mutations in ADAM11 are associated with some breast cancers. Retinoic acid caused a doubling in ADAM11 message levels over 24 hours in NT2/D1 cells, a human embryonic carcinoma cell line. ADAM11 null mutant mice have deficits in spatial learning and motor coordination, although they did have normal cell migration and differentiation during development. ADAM11 is a member of the ADAMs family (A Disintegrin And Metalloproteinase), but does not contain the canonical HExxHxxxxH zinc-binding metalloproteinase catalytic site. The domain structure of the full-length ADAM11 includes a signal sequence, propeptide domain, metalloproteinase-like domain, disintegrin-like domain, cys-rich domain, EGF-like domain, a spacer region, then the transmembrane domain and a short cytoplasmic domain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4782R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4782R-CY7
Lokale Artikelnummer::
BOSSBS-4782R-CY7
Beschreibung:
The heat shock proteins (HSPs) comprise a group of highly conserved, abundantly expressed proteins with diverse functions, including the assembly and sequestering of multi-protein complexes, transportation of nascent polypeptide chains across cellular membranes and regulation of protein folding. HSPB2 (heat shock 27 kDa protein 2), also known as HSP 27 or MKBP, is a 182 amino acid protein that belongs to the heat shock protein family and is expressed preferentially in heart and skeletal muscle. Localized to mitochondria, HSPB2 functions as an ATP-dependent chaperone protein that plays a role in the refolding of denatured proteins and may also interact with the Actin cytoskeleton and prevent apoptotic cell death. HSPB2 is abundantly expressed in several cancer cell lines, suggesting that HSPB2 may be an important factor in tumor transformation and metastasis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5471R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5471R-A647
Lokale Artikelnummer::
BOSSBS-5471R-A647
Beschreibung:
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5557R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5557R-CY5
Lokale Artikelnummer::
BOSSBS-5557R-CY5
Beschreibung:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4731R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4731R-HRP
Lokale Artikelnummer::
BOSSBS-4731R-HRP
Beschreibung:
ABP1
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4985R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4985R-CY3
Lokale Artikelnummer::
BOSSBS-4985R-CY3
Beschreibung:
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5691R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5691R-CY3
Lokale Artikelnummer::
BOSSBS-5691R-CY3
Beschreibung:
A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. The GTPase Rab24 is thought to be involved in the regulation of vesicular transport associated with autophagy.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5515R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5515R-CY7
Lokale Artikelnummer::
BOSSBS-5515R-CY7
Beschreibung:
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5467R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5467R-CY5
Lokale Artikelnummer::
BOSSBS-5467R-CY5
Beschreibung:
Gamma Catenin is a common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of gamma Catenin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. It is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6721R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6721R-A350
Lokale Artikelnummer::
BOSSBS-6721R-A350
Beschreibung:
KIRREL2 is an immunoglobulin super family gene, it has been found to be expressed in beta cells of pancreatic islets; KIRR2_HUMAN.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6079R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6079R-A555
Lokale Artikelnummer::
BOSSBS-6079R-A555
Beschreibung:
NPR2L is homologous to yeast nitrogen permease and is a candidate tumor suppressor, being a negative regulator of cell cycle. Most abundant in skeletal muscle, followed by brain, liver, and pancreas, with lower amounts in lung, kidney, placenta, and heart. Expressed in most lung cancer cell lines tested. There are two isoforms, produced by alternative splicing.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6030R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6030R-CY7
Lokale Artikelnummer::
BOSSBS-6030R-CY7
Beschreibung:
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1964R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1964R
Lokale Artikelnummer::
BOSSBS-1964R
Beschreibung:
Anti-KLK3 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8305R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8305R-CY5
Lokale Artikelnummer::
BOSSBS-8305R-CY5
Beschreibung:
The Lyl1 gene encodes a basic helix–loop–helix transcription factor involved in T-cell acute lymphoblastic leukemia. The expression of Lyl1 is at higher levels in the majority of cases of acute myeloblastic leukemia (AML) or myelodysplastic syndrome when compared to normal bone marrow. Lyl1 is highly expressed in most AML cell lines.Lyl-1, TAL1 and TAL2 are part of a family of basic helix-loop-helix (bHLH) proteins implicated in T cell acute leukemia. TAL1, also designated SCL, is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. TAL2 is a protein involved in T cell acute lymphoblastic leukemia through a chromosomal translocation involving TAL2 and T cell receptor ∫ chain genes. TAL2 includes a helix-loop-helix protein dimerization and DNA-binding domain that is homologous to TAL1 and Lyl-1 proto-oncogenes. Lyl-1 (lymphoblastic leukemia-derived sequence 1) is a nuclear protein. Endogenous Lyl-1 exists in complex with E2å proteins. Lyl-1 and E2å protein can form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells. Lyl-1 is involved in a chromosomal aberration which causes a form of T cell acute lymphoblastic leukemia (T-ALL).
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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