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BIOSS INC
Artikel-Nr:
(BOSSBS-1050R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1050R-A647
Lokale Artikelnummer::
BOSSBS-1050R-A647
Beschreibung:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3216R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3216R-CY3
Lokale Artikelnummer::
BOSSBS-3216R-CY3
Beschreibung:
HDAC7 is a member of the class II mammalian histone deacetylases, which plays an important role in modulating the eukaryotic chromatin structure. Human HDAC7 is composed of 912 amino acid residues. Although HDAC7 is localized mostly to the cell nucleus, it is also found in the cytoplasm, suggesting nucleo-cytoplasmic shuttling. The histone deacetylase activity of HDAC7 maps to a carboxy-terminal domain and is dependent on interaction with class I HDACs in the nucleus. It is an active component of different transcriptional corepressor complexes that can be recruited to specific promoter regions via interactions with a growing number of sequence specific transcriptional factors. HDAC7 catalyzes removal of acetyl-groups from acetyl-lysines of histones and promotes compaction of chromatin in these regions, leading to the inhibition of gene transcription.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5460R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5460R-A680
Lokale Artikelnummer::
BOSSBS-5460R-A680
Beschreibung:
The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarisation of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2661R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2661R-A750
Lokale Artikelnummer::
BOSSBS-2661R-A750
Beschreibung:
MD1 is a 28 kDa molecule that is associated at the cell surface with RP105 (CD180). RP105 is a leucine-rich repeat (LRR) molecule that is expressed on B lymphocytes. It was first identified by a mAb that protects spleen B cells from irradiation-induced apoptosis. LRR proteins, such as Toll receptors, have a role in innate immunity. MD1 is primarily expressed by B cells, dendritic cells and monocytes, and promotes the recognition of, and subsequent signaling by LPS in the innate immune system. MD1 does not have any homology to other molecules. MD1 when expressed alone behaves as a secretory protein. Expression of MD1 in a cell increases the expression of RP105.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8359R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8359R-A680
Lokale Artikelnummer::
BOSSBS-8359R-A680
Beschreibung:
The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerisation domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. The Kelch domain-containing protein 9 (KLHDC9), also designated Kelch/ankyrin repeat-containing cyclin A1-interacting protein (KARCA1), contains 3 Kelch repeats and interacts with CCNA1. The gene encoding KLHDC9 maps to chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene of human chromosome 1, which encodes lamin A. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7933R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7933R-A750
Lokale Artikelnummer::
BOSSBS-7933R-A750
Beschreibung:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localisation of the catalytic enzyme to a particular subcellular compartment.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1470R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1470R-A488
Lokale Artikelnummer::
BOSSBS-1470R-A488
Beschreibung:
Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5506R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5506R-A647
Lokale Artikelnummer::
BOSSBS-5506R-A647
Beschreibung:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. MAPK11 is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9027R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9027R-A488
Lokale Artikelnummer::
BOSSBS-9027R-A488
Beschreibung:
This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7084R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7084R
Lokale Artikelnummer::
BOSSBS-7084R
Beschreibung:
Anti-NOD2 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15386R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15386R
Lokale Artikelnummer::
BOSSBS-15386R
Beschreibung:
Anti-GPR162 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12463R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12463R
Lokale Artikelnummer::
BOSSBS-12463R
Beschreibung:
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7950R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7950R-CY5
Lokale Artikelnummer::
BOSSBS-7950R-CY5
Beschreibung:
ACBD4 is a member of the acyl-coenzyme A binding domain containing protein family. ACBD4 contains 1 ACB (acyl-CoA-binding) domain. There are three isoforms. Its function is unknown.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5231R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5231R-HRP
Lokale Artikelnummer::
BOSSBS-5231R-HRP
Beschreibung:
Bid, a BH3 domain containing proapoptotic Bcl2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase 8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent proapoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In animal model studies, Bid deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6164R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6164R-A350
Lokale Artikelnummer::
BOSSBS-6164R-A350
Beschreibung:
Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8013R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8013R-CY5.5
Lokale Artikelnummer::
BOSSBS-8013R-CY5.5
Beschreibung:
CHORDC3 is a muscle-specific protein that interacts with the Integrin 1 cytoplasmic domain, in the hypertrophic response to mechanical overload.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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