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BIOSS INC
Artikel-Nr:
(BOSSBS-7776R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7776R-CY7
Lokale Artikelnummer::
BOSSBS-7776R-CY7
Beschreibung:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.Tissue specificity:Detected in spleen, thymus, testis, ovary, small intestine and colon, with highest levels of expression in testis and ovary.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6102R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6102R-A750
Lokale Artikelnummer::
BOSSBS-6102R-A750
Beschreibung:
Isoform 5 and isoform 6 are highly expressed in the brain. Both isoforms derive from naturally occurring readthrough transcripts which produce IQCJ-SCHIP1 fusion proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11551R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11551R-A488
Lokale Artikelnummer::
BOSSBS-11551R-A488
Beschreibung:
Emx1 and Emx2 are human homologs to the Drosophila developmental genes empty spiracles expressed in anterior body regions during early Drosophila embryogenesis. Emx1 and Emx2 are homeobox proteins expressed in the developing vertebrate brain. Emx2 is expressed in the dorsal telencephalon and small diencephalic regions, while Emx1 expression is exclusively confined to pyramidal neurons of the dorsal telencephalon. In the embryonic brain, Emx1 is expressed in both proliferating and differentiating neurons while Emx2 is expressed only in proliferating neurons. OTX1 and OTX2 are human homologs of the Drosophila developmental genes orthodenticle. In development, the sequence of expression begins with OTX2 at day ten post coitum followed by OTX1, Emx2 and finally Emx1. The genes encoding human Emx1 and Emx2 map to chromosomes 2p13.2 and 10q26.11, respectively.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12527R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12527R-CY7
Lokale Artikelnummer::
BOSSBS-12527R-CY7
Beschreibung:
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11052R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11052R-HRP
Lokale Artikelnummer::
BOSSBS-11052R-HRP
Beschreibung:
HAS1, HAS2 and HAS3 are HA (hyaluronan or hyaluronic acid) synthase proteins. The extracellular matrix in most vertebrates express HA, which is a high molecular weight linear polysaccharide composed of alternating glucuronic acid and N-acetylglucosamine residues linked by b-1,3 and b-1,4 glycosidic bonds. The three HAS genes show distinct patterns of expression during development and their protein products play significantly different roles in the formation of the HA matrix. Both HAS1 and HAS2 synthesize high molecular-weight HA, whereas HAS3 produces lower molecular weight HA. The expression of the three HAS isoforms is more prominent in growing cells than in resting cells and is differentially regulated by various stimuli, suggesting distinct functional roles of the three proteins. HAS3 produces both secreted and cell-associated forms of hyaluronan and is the most active of the three isoforms of this enzyme in adults. HAS3 gene expression plays a crucial role in the regulation of hyaluronan synthesis in the epidermis. Specifically, IFN-g markedly upregulates HAS3 mRNA, whereas TGF Beta downregulates HAS3 transcript levels. The human HAS3 gene maps to chromosome 16q22.1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11429R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11429R-FITC
Lokale Artikelnummer::
BOSSBS-11429R-FITC
Beschreibung:
Neuropeptides are regulators of synaptic transmission and their effects are mediated by G-protein coupled receptors. NPS (Neuropeptide S) is a 20 amino acid peptide cleaved from a larger precursor that contains a hydrophobic signal peptide and proteolytic cleavage processing sites. The N-terminal residue of NPS is always a serine regardless of the species. NPS is predominantly found in the central nervous system and plays an important role regulating sleep/wake functions, locomotion, arousal/anxiety responses and food intake. NPS functions by binding and activating its receptor, NPSR, and increasing intracellular calcium levels thereby acting as an excitatory transmitter. In addition, NPS stimulates the hypothalamo-pituitary adrenal (HPA) axis via the release of corticotropin-releasing factor (CRF) and arginine vasopressin (AVP). NPS and its receptor NPSR may also play a role in asthma pathogenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5718R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5718R-FITC
Lokale Artikelnummer::
BOSSBS-5718R-FITC
Beschreibung:
Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBSM-2279M-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BSM-2279M-A680
Lokale Artikelnummer::
BOSSBSM-2279M-A680
Beschreibung:
This gene encodes a single-pass type I transmembrane protein, which is a subunit of the endoplasmic reticulum membrane protein complex (EMC). Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6333R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6333R-HRP
Lokale Artikelnummer::
BOSSBS-6333R-HRP
Beschreibung:
Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.Involvement in disease: Defects in APOB are a cause of hypobetalipoproteinemia familial type 1 (FHBL1) . A disorder characterized by highly reduced plasma concentrations of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia.Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB). FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12229R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12229R-A350
Lokale Artikelnummer::
BOSSBS-12229R-A350
Beschreibung:
May be involved in transcriptional regulation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3821R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3821R-CY7
Lokale Artikelnummer::
BOSSBS-3821R-CY7
Beschreibung:
Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11997R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11997R-CY5
Lokale Artikelnummer::
BOSSBS-11997R-CY5
Beschreibung:
DDAH, a dimethylarginine dimethylaminohydrolase, hydrolyzes dimethyl arginine (ADMA) and monomethyl arginine (MMA), both inhibitors of nitric oxide synthases, and may be involved in in-vivo modulation of nitric oxide production (1,2). Impairment of DDAH causes ADMA accumulation and a reduction in cGMP generation (3). DDAH II, the predominant DDAH isoform in endothelial cells, facilitates the induction of nitric oxide synthesis by all-trans-Retinoic acid (atRA) (4). DDAH proteins are highly expressed in colon, kidney, stomach and liver tissues (1).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13685R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13685R-CY3
Lokale Artikelnummer::
BOSSBS-13685R-CY3
Beschreibung:
C17orf87 (chromosome 17 open reading frame 87) is a 145 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4033R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4033R-A350
Lokale Artikelnummer::
BOSSBS-4033R-A350
Beschreibung:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5165R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5165R-A750
Lokale Artikelnummer::
BOSSBS-5165R-A750
Beschreibung:
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localised in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11518R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11518R-A350
Lokale Artikelnummer::
BOSSBS-11518R-A350
Beschreibung:
Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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