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Proteine und Peptide
Artikel-Nr:
(PRSI90-347)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-347
Lokale Artikelnummer::
PRSI90-347
Beschreibung:
TIP60 is the catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex is required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. TIP60 directly acetylates and activates ataxia-telangiectasia mutated (ATM). In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.
VE:
1 * 2 µG
Artikel-Nr:
(PRSI90-298)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-298
Lokale Artikelnummer::
PRSI90-298
Beschreibung:
IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI3299P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3299P
Lokale Artikelnummer::
PRSI3299P
Beschreibung:
TIRP peptide is used for blocking the activity of TIRP antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI4339P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4339P
Lokale Artikelnummer::
PRSI4339P
Beschreibung:
TEM7 peptide is used for blocking the activity of TEM7 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI5647P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5647P
Lokale Artikelnummer::
PRSI5647P
Beschreibung:
Slc37A2 peptide is used for blocking the activity of Slc37A2 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-357)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-357
Lokale Artikelnummer::
PRSI90-357
Beschreibung:
Mitochondrial NMNAT isoform. Catalyses the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form of nicotinic acid mononucleotide (NAMN) as substrate with the same efficiency. Can use tiazofurin monophosphate as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyses the reverse reaction, i. e. the pyrophosphorolytic cleavage of NAD+. For the pyrophosphorolytic activity, mitochondrial NMNAT isoform can use NAD(+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP+, NADPH and NAADP+. Protects against axonal degeneration following injury.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-075)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-075
Lokale Artikelnummer::
PRSI92-075
Beschreibung:
Interferon Regulatory Factor 5 (IRF5) is a member of the IRF family. It contains one IRF tryptophan pentad repeat DNA-binding domain. IRF5 shuttles between the nucleus and the cytoplasm. IRF5 can form homodimer when it is phosphorylated. IRF5 functions as a transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Genetic variations in IRF5 are associated with susceptibility to systemic lupus erythematosus type 10. In addition, the genetic variations wil result in susceptibility to rheumatoid arthritis.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI96-503)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-503
Lokale Artikelnummer::
PRSI96-503
Beschreibung:
Lysosomal-associated membrane protein 1 (LAMP1) is also known as CD107a (Cluster of Differentiation 107a). LAMP1 / CD107a belongs to the LAMP family. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. CD107a has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI90-095)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-095
Lokale Artikelnummer::
PRSI90-095
Beschreibung:
FGF-21 (Fibroblast growth factor 21) stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of betaKlotho.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-314)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-314
Lokale Artikelnummer::
PRSI90-314
Beschreibung:
Cochlin is an extracellular matrix protein expressed in the cochlea and vestibule of the inner ear. Mutations in the cochlin gene are linked to the autosomal-dominant DFNA9 syndrome, a disorder characterised by hearing loss. Cochlin is also expressed in follicular dendritic cells of the spleen and the lymph nodes. The N-terminus of cochlin contains a LCCL domain also present in Factor C, a serine protease of the horseshoe crab Limulus, involved in activating the coagulation cascade in response to LPS. A recent study showed that in response to inflammation, LPS or bacterial infection, cochlin is cleaved by the proteases aggrecanases and secreted into blood circulation. The secreted cochlin (LCCL domain) seems to have a role in local cytokine production, recruitment of immune effector cells and bacterial clearance. Cochlin is secreted as two forms p8 and p18, whereas p18 being the glycosylated form of p8.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI5739P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5739P
Lokale Artikelnummer::
PRSI5739P
Beschreibung:
APC13 peptide is used for blocking the activity of APC13 antibody.
VE:
1 * 50 µG
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Indian hedgehog (IHH) is an essential signaling factor that is secreted in the gut, cartilage, and bone during embryonic development. IHH acts through the patched (PTC) receptor to induce transcriptional changes important for bone and cartilage development. IHH also induces the expression of parathyroid hormone-related peptide (PTHrP), which in turn mediates IHH activity during chondrocyte differentiation, forming a negative feedback loop.
Artikel-Nr:
(PRSI6129P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6129P
Lokale Artikelnummer::
PRSI6129P
Beschreibung:
ZBTB8 peptide is used for blocking the activity of ZBTB8 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI6491P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6491P
Lokale Artikelnummer::
PRSI6491P
Beschreibung:
HIG2 peptide is used for blocking the activity of HIG2 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-246)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-246
Lokale Artikelnummer::
PRSI91-246
Beschreibung:
Chloride Intracellular Channel Protein 2 (CLIC2) is a critical component of all living cells; it regulatescellular traffic of Chloride ion and it can be inserted into membranes anf form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions, channel activity depends on the pH. CLIC2 is involved in regulating membrane potential and organic solute transport. CLIC2 modulates the activity of RYR2 and inhibits Calcium influx. CLIC2 can be detected in the adult brain, liver, lung, heart, stomach, spleen and testis. It is expressed in fetal liver and adult skeletal muscle. CLIC2 is a potential candidate for one of many diseases linked to Xq28.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-459)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-459
Lokale Artikelnummer::
PRSI90-459
Beschreibung:
HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-kappaB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-kappaB inducing localised innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also causative agent of various diseases as it causes localised inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis.
VE:
1 * 25 µG
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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